THE ROLE OF THE SOD2 GENE ALA16VAL POLYMORPHISM IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION

Authors

  • T.A. Tojiboyev
  • U.H. Musashaykhov
  • M.R. Khidoyatova

Keywords:

superoxide dismutase 2, Ala16Val polymorphism, arterial hypertension, genetic predisposition, oxidative stress, antioxidant enzymes, cardiovascular genetics, single nucleotide polymorphism, hypertension pathogenesis, personalized medicine

Abstract

This study explores the link between the Ala16Val polymorphism of the SOD2
gene and arterial hypertension. In a case-control design 96 patients, 95 controls, the Ala/
Val genotype was associated with a higher hypertension risk OR: 2.0 overall; 2.8 for grade
3, while the Ala/Ala genotype showed a protective effect. These findings enhance understanding
of hypertension genetics and support personalized approaches to diagnosis and treatment.

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Published

2025-10-28

Issue

Vol. 5 No. 5 (2025): Multidiscipline proceedings of digital fashion conference

Section

Articles