ASSESSMENT OF THE COMPOSITION OF THE MICROFLORA OF THE OROPHARYNX AND INTESTINES IN CHILDREN WITH BRONCHOPULMONARY PATHOLOGY

Abstract

Gut microbiota is known to influence local immune homeostasis in the gut and
shape the developing immune system towards pathogen elimination and tolerance to self-antigens.
Although the lungs have long been considered sterile, recent evidence using next-generation
sequencing techniques has confirmed that the lower respiratory tract possesses its own local
microbiota. Since then, there has been growing evidence that local respiratory and gut microbiota
play a role in acute and chronic lung diseases in children. The concept of the so-called gut-lung
axis was created, which describes the mutual influence of the local microbiota on distal immune
mechanisms.