FEATURES OF ULTRASTRUCTURAL CHANGES OF THE GASTRIC MUCOSA IN EXPERIMENTAL MODELING OF ADJUVANT ARTHRITIS

Abstract

Rheumatoid arthritis (RA) remains a serious disease with an unfavorable
prognosis, which is steadily progressing in a fairly large number of patients (Nasonova
V.A., 1994). It is well known from the literature that NSAIDs, by inhibiting the
production of prostaglandins (PG), reduce the resistance of the gastric mucosa to the
aggressive effects of hydrochloric acid and pepsin, lead to the development of gastropathy,
which, in some cases, can threaten the lives of patients.